THE INFLUENCE OF ANESTHETIC TECHNIQUE UPON THE IMMUNE-RESPONSE TO HYSTERECTOMY - A COMPARISON OF PROPOFOL INFUSION AND ISOFLURANE

被引：49

作者：

PIRTTIKANGAS, CO

SALO, M

MANSIKKA, M

GRONROOS, J

PULKKI, K

PELTOLA, O

机构：

[1] UNIV TURKU,DEPT SURG,SF-20520 TURKU,FINLAND

[2] UNIV TURKU,DEPT PATHOL,SF-20520 TURKU,FINLAND

[3] UNIV TURKU,CENT HOSP,CENT LAB,SF-20520 TURKU,FINLAND

来源：

ANAESTHESIA | 1995年 / 50卷 / 12期

关键词：

ANESTHETICS; INTRAVENOUS; PROPOFOL; VOLATILE; ISOFLURANE; CELL-MEDIATED IMMUNITY; INTERLEUKIN-6; PHOSPHOLIPASES A2;

D O I：

10.1111/j.1365-2044.1995.tb05951.x

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Earlier studies on propofol have shown increased percentages of T helper cells after minor surgery. In this study, the effects of propofol infusion anaesthesia on the immune response were compared with those of combined isoflurane anaesthesia in 30 patients (median age 47 years, ASA 1-2) undergoing major surgery. The total dose of propofol in the propofol infusion group of 15 women was 860 mg (range 540-1520 mg) and the median end-expiratory isoflurane concentration in the combined isoflurane group of 15 women was 0.6% (range 0.5-0.8). The following were measured; leucocyte and differential counts; percentages of lymphocyte subpopulations (CD3, CD4, CD8, CD19, CD16 and HLA-DR + CD3); phytohaemagglutinin-, concanavalin A-, and pokeweed mitogen-induced and unstimulated lymphocyte proliferation; plasma interleukin-6; serum group Il phospholipase A2, C-reactive protein and cortisol concentrations. Measurements were made pre-operatively, at the end of the operation and on the first and fifth postoperative days. No statistically significant overall differences were observed in the immune response between the groups. The serum cortisol response,vas weaker in the propofol group than in the isoflurane group (p < 0.05). Time-related changes were seen within the groups.

引用

页码：1056 / 1061

页数：6

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