ANTI-UTEROTROPHIC RESPONSE OF IMMATURE MICE TO 3-METHYLCHOLANTHRENE

被引：8

作者：

NEWMAN, WC

MOON, RC

机构：

[1] Department of Physiology and Biophysics, University of Tennessee Medical Units, Memphis, TN

来源：

NATURE | 1969年 / 221卷 / 5175期

关键词：

D O I：

10.1038/221089a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

As well as its ability to induce cancer in various tissues, the polycyclic hydrocarbon 3-methylcholanthrene (MCA) is capable of affecting the activity of certain endocrine glands1-3 and altering the metabolism of several hormones4-7. Indirect evidence from several sources6,8-12 indicates that, in various experimental conditions, MCA may be capable of inhibiting, potentiating or mimicking the activity of certain steroid hormones. We have conducted preliminary experiments aimed at testing more rigorously the alleged steroidal activity of MCA. In the experiment reported here, MCA was tested for oestrogenic (uterotrophic) activity in a four point assay using oestrone as the reference standard. © 1969 Nature Publishing Group.

引用

页码：89 / &

共 14 条

[1]

ARCOS JC, 1961, J BIOL CHEM, V236, P1291

[2]

GLENN EM, 1959, ENDOCRINOLOGY, V64, P419

[3]

HERTZ R, 1947, J NATL CANCER I, V8, P121

[4] RAPID INDUCTION OF MAMMARY CARCINOMA IN THE RAT AND THE INFLUENCE OF HORMONES ON THE TUMORS [J].