THE SYNTHESIS OF CYCLIC-PEPTIDES USING FMOC SOLID-PHASE CHEMISTRY AND THE LINKAGE AGENT 4-(4-HYDROXYMETHYL-3-METHOXYPHENOXY)-BUTYRIC ACID

被引：14

作者：

MCMURRAY, JS

LEWIS, CA

机构：

[1] Department of Neuro-Oncology The University, Texas M. D. Anderson Cancer Center, Houston, TX 77030

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 50期

关键词：

CYCLIC PEPTIDE; SOLID-PHASE PEPTIDE SYNTHESIS; FMOC/T-BUTYL PROTECTION; 4-(4-HYDROXYMETHYL-3-METHOXYPHENOXY)-BUTYRIC ACID;

D O I：

10.1016/S0040-4039(00)61450-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three cyclic peptides were synthesized by first assembling the amino acid sequences on polystyrene resin derivatized with 4-(4-hydroxymethyl-3-methoxyphenoxy)-butyric acid (HMBA), cleaving the protected peptides from the solid support, and then cyclizing in solution.

引用

页码：8059 / 8062

页数：4

共 7 条

[1]

ATHERTON E, 1981, PEPTIDES SYNTHESIS S, P163

[2]

CASTRO B, 1975, TETRAHEDRON LETT, P1219

[3]

FLORSHEIMER A, 1990, 21ST P EUR PEPT S LE, P131

[4]

MCMURRAY JS, 1993, INT J PEPT PROT RES, V42, P209

[5] PEPTIDE-SYNTHESIS BY A COMBINATION OF SOLID-PHASE AND SOLUTION METHODS .1. A NEW VERY ACID-LABILE ANCHOR GROUP FOR THE SOLID-PHASE SYNTHESIS OF FULLY PROTECTED FRAGMENTS [J].

MERGLER, M ;

TANNER, R ;

GOSTELI, J ;

GROGG, P .

TETRAHEDRON LETTERS, 1988, 29 (32) :4005-4008

[6]

PATSCHINSKY T, 1982, P NATL ACAD SCI-BIOL, V79, P973, DOI 10.1073/pnas.79.4.973

[7]

SHEPPARD RC, 1982, INT J PEPT PROT RES, V20, P451

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