SYNTHESIS AND CARBAMOYLATION OF 1,2,3,4,5,6-HEXAHYDRO-1,3-DIMETHYL-2,6-METHANO-1,3-BENZODIAZOCIN-8-OL - BRIDGED ANALOGS OF PHYSOSTIGMINE

被引：8

作者：

FINK, DM

ALLEN, RC

机构：

[1] Hoechst-Roussel Pharmaceuticals Inc., Somerville, NJ 08876

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 16期

关键词：

D O I：

10.1016/0040-4039(92)88151-T

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis and carbamoylation of 2,6-methano-1,3-benzodiazocin-8-ol is described. A one pot silyl-aryl ether to carbamate transformation was developed. The compounds are analogues of the cholinesterase inhibitor physostigmine.

引用

页码：2103 / 2106

页数：4

共 10 条

[1] CYANOHYDRIDOBORATE ANION AS A SELECTIVE REDUCING AGENT [J].

BORCH, RF ;

BERNSTEIN, MD ;

DURST, HD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1971, 93 (12) :2897-+

[2] A NEW AND RAPID COLORIMETRIC DETERMINATION OF ACETYLCHOLINESTERASE ACTIVITY [J].

ELLMAN, GL ;

COURTNEY, KD ;

ANDRES, V ;

FEATHERSTONE, RM .

BIOCHEMICAL PHARMACOLOGY, 1961, 7 (02) :88-&

[3] INHIBITION OF [NALOXONE-H-3 BINDING IN HOMOGENATES OF RAT-BRAIN BY ESEROLINE, A DRUG, WITH ANALGESIC ACTIVITY, RELATED TO PHYSOSTIGMINE [J].

GALLI, A ;

RENZI, G ;

BARTOLINI, A ;

BARTOLINI, R ;

MALMBERGAIELLO, P .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1979, 31 (11) :784-786

[4]

HAMER RRI, UNPUB

[5]

KAMETANI T, 1965, PHARM B, V13, P1220

[6]

KAMETANI T, 1974, HETEROCYCLES, V2, P349

[7]

KANAZAWA R, 1976, SYNTHESIS-STUTTGART, P526

[8]

KRAPCHO AP, 1973, TETRAHEDRON LETT, P957

[9]

1984, Patent No. 4424150

[10]

1991, SCRIPT, P22

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