ANTI BETA-2-GLYCOPROTEIN-I ANTIBODIES IN A PATIENT WITH CATASTROPHIC ANTIPHOSPHOLIPID SYNDROME

被引：8

作者：

PENGO, V ^{[1
]}

BIASIOLO, A ^{[1
]}

FIOR, MG ^{[1
]}

RUFFATTI, A ^{[1
]}

机构：

[1] UNIV PADUA,SCH MED,CTR THROMBOSIS,DEPT CARDIOL,PADUA,ITALY

来源：

CLINICAL RHEUMATOLOGY | 1995年 / 14卷 / 06期

关键词：

ANTIPHOSPHOLIPID ANTIBODIES; BETA-2-GLYCOPROTEIN I; ANTIPHOSPHOLIPID SYNDROME;

D O I：

10.1007/BF02207930

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autoimmune antiphospholipid antibodies are a hallmark of patients with antiphospholipid syndrome, and require a protein cofactor, beta 2-glycoprotein I, to bind anionic phospholipids. In these same patients, moreover, IgG directly binding beta 2-glycoprotein I are described. We found high plasma titres of both IgM and IgG anti beta 2-glycoprotein I antibodies in a patient with catastrophic antiphospholipid syndrome. After passing plasma through a Sephacryl S-300 column, an identical distribution pattern between anti beta 2-glycoprotein I and anticardiolipin antibodies was observed, Moreover, when IgG immunocomplexes were isolated from a high molecular fraction, IgM anti-beta 2-glycoprotein I and anticardiolipin antibodies were detected, Thus IgG, IgM ad IgG-IgM complexes of anti-beta 2-glycoprotein I antibodies are present at the same time in a patient with antiphospholipid syndrome.

引用

页码：646 / 649

页数：4

共 16 条

[1]

Harris E.N., Gharavi A.E., Hughes G.R.V., Anti-phospholipid antibodies, Clin Rheum Dis, 11, pp. 591-609, (1985)

[2]

McNeil H.P., Simpson R.J., Chesterman C.N., Krillis S.A., Antiphospholipid antibodies are directed against a complex antigen that includes a lipid binding inhibitor of coagulation: β2-Glycoprotein-I (Apolipoprotein H), Proc Natl Acad Sci USA, 87, pp. 4120-4124, (1990)

[3]

Galli M., Comfurius P., Maassen C., Hemker H.C., De Baets M.H., Van Brieda-Vriesman P.J.C., Barbui T., Zwaal R.F.A., Bevers E.M., Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor, Lancet, 335, pp. 1544-1547, (1990)

[4]

Matsuura E., Igarashi Y., Fujimoto M., Ichikava K., Koike T., Anticardiolipin cofactor(s) and differential diagnosis of autoimmune disease, Lancet, 336, pp. 177-178, (1990)

[5]

Viard J.P., Amoura Z., Bach J.F., Association of anti β2-glycoprotein I antibodies with lupus-type circulating anticoagulant and thrombosis in systemic lupus erythematosus, Am J Med, 93, pp. 181-186, (1992)

[6]

Ruffatti A., De Silvestro G., Ghirardello A., Calligaro A., Del Ross T., Thiene G., Todesco S., A catastrophic antiphospholipid syndrome: the importance of high levels of warfarin anticoagulation, J Int Med, 235, pp. 81-83, (1994)

[7]

Gharavi A.E., Harris E.N., Asherson R.A., Hughes G.R.V., Anticardiolipin antibodies: isotype distribution and phospholipid specificity, Ann Rheum Dis, 46, pp. 1-6, (1987)

[8]

Biasiolo A., Pengo V., Antiphospholipid antibodies are not present in the membrane of gel-filtered platelets of patients with IgG anticardiolipin antibodies, lupus anticoagulant and thrombosis, Blood Coag Fibrinol, 4, pp. 425-428, (1993)

[9]

Thiagarajan P., Pengo V., Shapiro S.S., The use of dilute Russell Viper Venom Time for the diagnosis of lupus anticoagulants, Blood, 68, pp. 869-873, (1986)

[10]

Polz E., Wurm H., Kostner G.M., Investigation on β2-glycoprotein I in the rat: isolation from serum and demonstration in lipoprotein density fractions, Int J Biochem, 11, pp. 265-270, (1980)

← 1 2 →