STEREOSELECTIVE SYNTHESIS AND EVALUATION OF ALL STEREOISOMERS OF Z4349, A NOVEL AND SELECTIVE MU-OPIOID ANALGESIC

被引：7

作者：

NAPOLETANO, M ^{[1
]}

DELLA, BD ^{[1
]}

FRAIRE, C ^{[1
]}

GRANCINI, G ^{[1
]}

MASOTTO, C ^{[1
]}

RICCIARDI, S ^{[1
]}

ZAMBON, C ^{[1
]}

机构：

[1] UNIV MILAN,DEPT PHARMACOL CHEMOTHERAPY & MED TOXICOL,MILAN,ITALY

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 06期

关键词：

D O I：

10.1016/0960-894X(95)00077-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A stereoselective synthesis of 1 was devised in order to obtain all 12 possible isomers. The pharmacological data clearly show a highly stereochemical requirement for the affinity and selectivity towards the mu-receptor and the related analgesic activity.

引用

页码：589 / 592

页数：4

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