PA-I AND PA-II LECTIN INTERACTIONS WITH THE ABO(H)-BLOOD AND P-BLOOD GROUP GLYCOSPHINGOLIPID ANTIGENS MAY CONTRIBUTE TO THE BROAD-SPECTRUM ADHERENCE OF PSEUDOMONAS-AERUGINOSA TO HUMAN TISSUES IN SECONDARY INFECTIONS

被引：65

作者：

GILBOAGARBER, N ^{[1
]}

SUDAKEVITZ, D ^{[1
]}

SHEFFI, M ^{[1
]}

SELA, R ^{[1
]}

LEVENE, C ^{[1
]}

机构：

[1] MINIST HLTH,BLOOD GRP REFERENCE LAB,JERUSALEM,ISRAEL

来源：

GLYCOCONJUGATE JOURNAL | 1994年 / 11卷 / 05期

关键词：

PSEUDOMONAS AERUGINOSA ADHERENCE; LECTIN INTERACTIONS; GLYCOSPHINGOLIPID ANTIGENS; ABO BLOOD GROUP; P SYSTEM ANTIGENS;

D O I：

10.1007/BF00731276

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pseudomonas aeruginosa may cause serious infections in most human tissues/organs. Its adherence to them is mediated by a battery of adhesins including the PA-I and PA-II lectins, which are produced in this bacterium in high quantities. PA-I binds to the D-galactose of the erythrocyte glycosphingolipids exhibiting highest affinities for B and P-k (followed by P-1) antigens, while PA-II preferentially binds to the L-fucose of H, A and B antigens. Intact P. aeruginosa cells also exhibit a clear P-k and P-1 over p preference. Such affinities for the most common human ABH and P system antigens may underlie the widespread tissue infectivity and pathogenicity of this bacterium.

引用

页码：414 / 417

页数：4

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