THE ORDER OF HEPATIC CYTOTOXICITY OF BILE-SALTS INVITRO DOES NOT AGREE WITH THAT EXAMINED INVIVO IN RATS

Using an enzyme release from isolated rat hepatocytes incubated with a bile salt as a marker, the cytotoxic order of bile salts was found to be taurochenodeoxycholate, glycochenodeoxycholate > tauroursodeoxycholate, glycoursodeoxycholate, cholate > taurocholate, glycocholate. Thus, the cytotoxicity of conjugates of ursodeoxycholate was greater than that of conjugates of cholate. However, these data do not agree with the order of cytotoxicity of these bile salts previously studied in vivo by the authors which demonstrated the least cytotoxic nature of conjugates of ursodeoxycholate. © 1990.