DIFFERENCES IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) ANTI-P24 REACTIVITIES IN SERUM OF HIV-1-INFECTED AND UNINFECTED SUBJECTS - ANALYSIS OF INDETERMINATE WESTERN-BLOT REACTIONS

被引:20
作者
POVOLOTSKY, J
GOLD, JWM
CHEIN, N
BARON, P
ARMSTRONG, D
机构
[1] MEM SLOAN KETTERING CANC CTR,INFECT DIS SERV,1275 YORK AVE,NEW YORK,NY 10021
[2] MEM SLOAN KETTERING CANC CTR,SPECIAL MICROBIOL LAB,NEW YORK,NY 10021
关键词
D O I
10.1093/infdis/163.2.247
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Anti-p24 reactions in sera from 42 human immunodeficiency virus type 1 (HIV-1)-infected and 36 uninfected people with indeterminate Western blot antibody tests for HIV-1 were studied. Anti-p24 reactivity in HIV-1-infected people was completely blocked by HIV-1 recombinant p24 antigen, whereas the reaction in uninfected individuals with indeterminate patterns was inhibited partly or not at all. In contrast to infected individuals, anti-p24 reactivity from uninfected individuals could not be detected by an inhibition ELISA for HIV-1 p24 antibody. These results suggest a practical way to distinguish anti-p24 reactivity in sera from patients with HIV-1 infection from that seen in uninfected patients with indeterminate Western blot reactions.
引用
收藏
页码:247 / 251
页数:5
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