CELL-PROLIFERATION IN BREAST-CARCINOMA ASSESSED BY A PCNA GRADING SYSTEM AND ITS RELATION TO OTHER PROGNOSTIC VARIABLES

被引：11

作者：

BETTA, PG

PAVESI, M

PASTORMERLO, M

BELLINGERI, D

TALLARIDA, F

机构：

[1] Service of Pathological Anatomy and Cytopathology, 'Santo Spirito' Hospital, Casale Monferrato

[2] Department of Radiotherapy, City Hospital, Alessandria

[3] Department of Pathology, City Hospital, Alessandria

来源：

SURGICAL ONCOLOGY-OXFORD | 1993年 / 2卷 / 01期

关键词：

BREAST CANCER; IMMUNOHISTOCHEMISTRY; PC10-MAB; PCNA; PROGNOSTIC FACTOR; PROLIFERATION RATE;

D O I：

10.1016/0960-7404(93)90045-Z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study was undertaken to relate the expression of the proliferating cell nuclear antigen (PCNA), a proliferation marker of putative prognostic significance, to some more established prognostic factors in a series of 60 consecutive breast cancer surgical specimens. PCNA was detected by the PC10 monoclonal antibody (MAb) using an immunohistochemical method and PCNA immunostaining was estimated on a semi-quantitative basis, a cut-off value of 50% of positively stained tumour cells discriminating between the high (>50%) and low (<50%) PCNA grade. The PCNA grade did not correlate with tumour size and axillary node status. However, a high PCNA grade tended to be associated with a poor histological grade and there was an inverse relationship with oestrogen-receptor status, as determined by means of the immunohistochemical staining for the oestrogen-induced pS2 protein. These conflicting results suggest that the possible prognostic usefulness of PCNA immunostaining, as a measure of cell proliferation rate, in breast cancer is yet to be demonstrated and can be validated only by direct relation to survival data.

引用

页码：59 / 63

页数：5

共 21 条

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