CHEMOPREVENTIVE EFFECT OF TURMERIC AGAINST STOMACH AND SKIN TUMORS INDUCED BY CHEMICAL CARCINOGENS IN SWISS MICE

被引：240

作者：

AZUINE, MA ^{[1
]}

BHIDE, SV ^{[1
]}

机构：

[1] TATA MEM HOSP,CANC RES INST,DIV CARCINOGENESIS,BOMBAY 400012,INDIA

来源：

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 1992年 / 17卷 / 01期

关键词：

D O I：

10.1080/01635589209514174

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The anticarcinogenic effect of dietary turmeric on benzo[a]pyrene-(BP) induced fore-stomach neoplasia and 7,12-dimethylbenz[a]anthracene (DMBA)-induced skin tumorigenesis in female Swiss mice was evaluated. To further elucidate the mechanism of antineoplastic action of turmeric, its effect on the hepatic cytochrome b5, cytochrome P-450, glutathione, and glutathione S-transferase activities was studied in female Swiss mice. Turmeric (2% or 5%) in the diet significantly inhibited the BP-induced forestomach tumors, and this response was dose and time dependent. The 2% turmeric diet significantly suppressed DMBA-induced skin tumors in mice. The 5% turmeric diet for seven consecutive days resulted in a 38% decrease in the hepatic cytochrome b5 and cytochrome P-450 levels. Glutathione content was increased by 12%, and the glutathione S-transferase activity was enhanced by 32% in the liver. Our results document a protective effect of turmeric on BP-induced forestomach and DMBA-induced skin tumors in mice.

引用

页码：77 / 83

页数：7

共 24 条

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