STIMULATION OF NERVE GROWTH-FACTOR SYNTHESIS AND SECRETION BY FELLUTAMIDE-A INVITRO

被引：39

作者：

YAMAGUCHI, K ^{[1
]}

TSUJI, T ^{[1
]}

WAKURI, S ^{[1
]}

YAZAWA, K ^{[1
]}

KONDO, K ^{[1
]}

SHIGEMORI, H ^{[1
]}

KOBAYASHI, J ^{[1
]}

机构：

[1] HOKKAIDO UNIV, FAC PHARMACEUT SCI, SAPPORO, HOKKAIDO 060, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1993年 / 57卷 / 02期

关键词：

D O I：

10.1271/bbb.57.195

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fellutamide A, a tripeptide derivative from Penicillium fellutanum was found to be a potent enhancer of nerve growth factor (NGF) synthesis and secretion in vitro. This compound enhanced production of NGF in L-M cells, rat brain cells, and rat glial cells. The mode of action of this compound was suggested to be different from that of a known NGF inducer, epinephrine, as inducing activities of fellutamide A and epinephrine were additive when they were admixed at the concentration which gave saturation in its respective activity. Furthermore, fellutamide A but not epinephrine induced production of NGF in the rat brain cells. NGF-inducing activity of several tripeptides and other compounds related to fellutamide A was examined.

引用

页码：195 / 199

页数：5

共 19 条

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