SULFOXIDES AS LEAVING GROUPS - EFFECT OF STERICALLY HINDERED ALIPHATIC SULFOXIDES ON THE ANTITUMOR-ACTIVITY OF CHLORO(SUBSTITUTED SULFOXIDE)(1,1-DIAMINOMETHYLCYCLOHEXANE)PLATINUM(II) NITRATE

被引：32

作者：

LANDI, J

HACKER, MP

FARRELL, N

机构：

[1] VERMONT CANC CTR,DEPT CHEM,BURLINGTON,VT 05405

[2] VERMONT CANC CTR,DEPT PHARMACOL,BURLINGTON,VT 05405

来源：

INORGANICA CHIMICA ACTA | 1992年 / 202卷 / 01期

关键词：

D O I：

10.1016/S0020-1693(00)85354-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The preparation and spectral properties of a series of complexes of general formula [PtCl(R'R"SO)(1,1-diaminomethylcyclohexane)]NO3 (R'R"SO=substituted sulfoxide) is reported. The complexes were studied for cytotoxicity and antitumor efficacy where high activity was seen for n-propyl- and n-butylsulfoxide derivatives. The results confirm previous reports that the biological activity of this series is dependent on the nature of the sulfur ligand and extends the type of useful sulfoxides to sterically hindered aliphatic ligands.

引用

页码：79 / 83

页数：5

共 11 条

[1]

ADOMAT H, 1991, Anti-Cancer Drug Design, V6, P233

[2]

Cleare M.J., 1973, BIOINORG CHEM, V2, P187, DOI DOI 10.1016/S0006-3061(00)80249-5

[3] SPECTROSCOPIC AND STRUCTURAL-PROPERTIES OF DIMETHYLSULFOXIDE, DIPHENYLSULFOXIDE AND METHYLPHENYLSULFOXIDE PLATINUM COMPLEXES - THE CRYSTAL AND MOLECULAR-STRUCTURES OF CIS-DICHLOROBIS(METHYLPHENYLSULFOXIDE)-PLATINUM(II) AND POTASSIUMTRICHLORO(PHENYLSULFOXIDE)PLATINUM(II)-ACETONE SOLVATE [J].