BIOCHEMICAL-PROPERTIES AND FUNCTION OF POLY(ADP-RIBOSE) GLYCOHYDROLASE

被引：31

作者：

DESNOYERS, S

SHAH, GM

BROCHU, G

HOFLACK, JC

VERREAULT, A

POIRIER, GG

机构：

[1] CHUL,RES CTR,MOLEC ENDOCRINOL LAB,HLTH & ENVIRONM UNIT,POLYADP RIBOSE METAB GRP,ST FOY,PQ G1V 4G2,CANADA

[2] CTR SCI ENVIRONNEMENT,F-57040 METZ 01,FRANCE

[3] COLD SPRING HARBOR LAB,COLD SPRING HARBOR,NY 11724

来源：

BIOCHIMIE | 1995年 / 77卷 / 06期

关键词：

POLY(ADP-RIBOSE) GLYCOHYDROLASE; ACTIVITY GEL; ISOFORMS; ENDO-EXOGLYCOSIDIC ACTIVITY;

D O I：

10.1016/0300-9084(96)88156-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe here the latest observations on poly(ADP-ribose) glycohydrolase. There is now extensive evidence that this nuclear enzyme is an endo-exoglycosidase which has a key role to perform in the removal of polymers which interact with proteins through covalent and non-covalent interactions. Also, we have developed a zymogram which will permit the isolation of the various isoforms of the glycohydrolase and the eventual cloning of this enzyme. Finally, we have evidence that very short oligomers and even monomers of ADP-ribose covalently bound to proteins can be removed by poly(ADP-ribose) glycohydrolase.

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页码：433 / 438

页数：6

相关论文

共 44 条

[1] CHARACTERIZATION OF POLYMERS OF ADENOSINE-DIPHOSPHATE RIBOSE GENERATED INVITRO AND INVIVO [J].

ALVAREZGONZALEZ, R ;

JACOBSON, MK .

BIOCHEMISTRY, 1987, 26 (11) :3218-3224

[2] POLY(ADP-RIBOSE) CATABOLISM IN MAMMALIAN-CELLS EXPOSED TO DNA-DAMAGING AGENTS [J].

ALVAREZGONZALEZ, R ;

ALTHAUS, FR .

MUTATION RESEARCH, 1989, 218 (02) :67-74

[3] MACROMOLECULAR ASSOCIATION OF ADP-RIBOSYLTRANSFERASE AND ITS CORRELATION WITH ENZYMATIC-ACTIVITY [J].

BAUER, PI ;

BUKI, KG ;

HAKAM, A ;

KUN, E .

BIOCHEMICAL JOURNAL, 1990, 270 (01) :17-26

[4] ENDOGLYCOSIDIC CLEAVAGE OF BRANCHED POLYMERS BY POLY(ADP-RIBOSE) GLYCOHYDROLASE [J].

BRAUN, SA ;

PANZETER, PL ;

COLLINGE, MA ;

ALTHAUS, FR .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1994, 220 (02) :369-375

[5] MODE OF ACTION OF POLY(ADP-RIBOSE) GLYCOHYDROLASE [J].

BROCHU, G ;

DUCHAINE, C ;

THIBEAULT, L ;

LAGUEUX, J ;

SHAH, GM ;

POIRIER, GG .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1994, 1219 (02) :342-350

[6] PURIFICATION OF POLY(ADP-RIBOSE) GLYCOHYDROLASE AND DETECTION OF ITS ISOFORMS BY A ZYMOGRAM FOLLOWING ONE-DIMENSIONAL OR 2-DIMENSIONAL ELECTROPHORESIS [J].

BROCHU, G ;

SHAH, GM ;

POIRIER, GG .

ANALYTICAL BIOCHEMISTRY, 1994, 218 (02) :265-272

[7] EVIDENCE FOR 2 VARIANTS OF POLY(ADENOSINE DIPHOSPHATE RIBOSE) GLYCOHYDROLASE IN RAT TESTIS [J].

BURZIO, LO ;

RIQUELME, PT ;

OHTSUKA, E ;

KOIDE, SS .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1976, 173 (01) :306-319

[8] ENZYMOLOGICAL PROPERTIES OF POLY(ADP-RIBOSE) POLYMERASE - CHARACTERIZATION OF AUTOMODIFICATION SITES AND NADASE ACTIVITY [J].

DESMARAIS, Y ;

MENARD, L ;

LAGUEUX, J ;

POIRIER, GG .

BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1078 (02) :179-186

[9] ERASABLE BLOT OF POLY(ADP-RIBOSE) POLYMERASE [J].

DESNOYERS, S ;

SHAH, GM ;

BROCHU, G ;

POIRIER, GG .

ANALYTICAL BIOCHEMISTRY, 1994, 218 (02) :470-473

[10]

HATAKEYAMA K, 1986, J BIOL CHEM, V261, P4902

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