STUDIES ON THE METABOLITES OF HIGHER FUNGI .9. INVESTIGATION OF THE BIOSYNTHESIS OF 3-ALPHA-HYDROXY TRITERPENOIDS, GANODERIC ACID-T AND ACID-S BY APPLICATION OF A FEEDING EXPERIMENT USING [1,2-(C2)-C-13]ACETATE

被引：30

作者：

HIROTANI, M ^{[1
]}

ASAKA, I ^{[1
]}

FURUYA, T ^{[1
]}

机构：

[1] KITASATO UNIV,SCH PHARMACEUT SCI,MINATO KU,TOKYO 108,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1990年 / 10期

关键词：

D O I：

10.1039/p19900002751

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The biosynthesis of 3α-acetoxy and 3α-hydroxytriterpenoids, ganoderic acids T and S, in cultured mycelia of Ganoderma lucidum fed with [1,2-13C2]acetate, was investigated by 13C NMR spectroscopy. The 13C-labelling patterns of ganoderic acids T and S indicate that (3S)-squalene 2,3-epoxide is a precursor of 3α-hydroxy triterpenoids in higher fungi as well as of those in higher plants.

引用

页码：2751 / 2754

页数：4

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