INTERLEUKIN-6 (IL-6) IN ADJUVANT ARTHRITIS OF RATS AND ITS PHARMACOLOGICAL MODULATION

被引：40

作者：

THEISENPOPP, P ^{[1
]}

PAPE, H ^{[1
]}

MULLERPEDDINGHAUS, R ^{[1
]}

机构：

[1] TROPONWERKE GMBH & CO KG,DEPT ANTIPHLOGIST RES,BERLINER STR 156,W-5000 COLOGNE 80,GERMANY

来源：

INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | 1992年 / 14卷 / 04期

关键词：

D O I：

10.1016/0192-0561(92)90117-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The levels of serum interleukin-6 (IL-6) were measured during the course of adjuvant arthritis (FAA) in male Lewis rats. In the course of the disease serum IL-6 levels increase with a clear correlation with morphologic disease signs. Additionally, the FAA-inducing antigen, heat-killed Mycobacterium tuberculosis, was found to be a strong inducer of IL-6 production by spleen cells in vitro. The effects of the anti-rheumatic drugs indometacin, dexamethasone, cyclophosphamide and cyclosporin A (CsA) on IL-6 levels during FAA were determined. Complete normalization of serum IL-6 levels was observed with dexamethasone, cyclophosphamide and CsA whereas indometacin only partly reduced serum IL-6 levels.

引用

页码：565 / 571

页数：7

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