GAMMA-PYRONE COMPOUNDS .2. SYNTHESIS AND ANTIPLATELET EFFECTS OF TETRAOXYGENATED XANTHONES

被引：37

作者：

LIN, CN ^{[1
]}

LIOU, SRS ^{[1
]}

KO, FN ^{[1
]}

TENG, CM ^{[1
]}

机构：

[1] NATL TAIWAN UNIV,COLL MED,INST PHARMACOL,TAIPEI 10018,TAIWAN

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1992年 / 81卷 / 11期

关键词：

D O I：

10.1002/jps.2600811114

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Norathyriol and its analogues, 1,3,5,6-,3,4,5,6-,3,4,6,7- and 2,3,6,7-tetrahydroxyxanthone, were synthesized from benzophenone precursors by Friedel-Crafts acylation and subsequent base-catalyzed cyclization to eliminate methanol. Both 3,4,6,7- and 2,3,6,7-tetrahydroxyxanthone tetraacetate showed potent anti-platelet aggregation effects on arachidonic acid-induced platelet aggregation. 3,4,6,7-Tetrahydroxyxanthone tetraacetate and 1,3,5,6-tetrahydroxyxanthone showed potent and significant anti-platelet aggregation effects on collagen-induced platelet aggregation.

引用

页码：1109 / 1112

页数：4

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