EFFECT OF SOME POLYMERS ON THE PHYSICOCHEMICAL AND DISSOLUTION PROPERTIES OF HYDROCHLOROTHIAZIDE-II

被引：15

作者：

SIMONELLI, AP

MESHALI, MM

ELGAWAD, AHA

ABDELALEEM, HM

GABR, KE

机构：

[1] MANSOURA UNIV,FAC PHARM,MANSOURA,EGYPT

[2] UNIV CONNECTICUT,SCH PHARM,STORRS,CT

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1994年 / 20卷 / 17期

关键词：

D O I：

10.3109/03639049409042677

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Different ratios of hydrochlorothiazide (HCT) and each of Polyethylene glycol (PEG) and B-cyclodextrin (B-CD) solid dispersions were prepared by melting and solvent method respectively, The solid dispersions were subjected to X-ray diffraction, I.R. spectroscopy, DSC and Dissolution from constant surface tablets. The drug was in the amorphous form when the ratios of the drug/PEG were less than 1:3. It formed hydrogen bond with both polymers. The dissolution of the drug from drug/PEG and drug/B-CD solid dispersions increased with the increase in the weight fraction of the polymers, reaching a maximum and then decreased with further increase of the latters.

引用

页码：2741 / 2752

页数：12

共 11 条

[1] PHARMACEUTICAL APPLICATIONS OF SOLID DISPERSION SYSTEMS - X-RAY-DIFFRACTION AND AQUEOUS SOLUBILITY STUDIES ON GRISEOFULVIN-POLYETHYLENE GLYCOL 6000 SYSTEMS [J].