THE SOLVENT DEPENDENCE OF ENZYME SPECIFICITY

被引：278

作者：

WESCOTT, CR ^{[1
]}

KLIBANOV, AM ^{[1
]}

机构：

[1] MIT,DEPT CHEM,CAMBRIDGE,MA 02139

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY | 1994年 / 1206卷 / 01期

关键词：

ENZYME; SPECIFICITY; ORGANIC SOLVENT; ENANTIOSELECTIVITY; REGIOSELECTIVITY;

D O I：

10.1016/0167-4838(94)90065-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The discovery that enzymes possess catalytic activity in organic solvents has made it possible to address the question of the influence of the reaction medium on enzymatic specificity. Recently, the substrate specificity, enantioselectivity, prochiral selectivity, regioselectivity, and chemoselectivity of enzymes have been found to dramatically depend on the nature of the solvent. This review discusses the scope, possible mechanisms, and implications of this phenomenon, as well as directions of future research in the area.

引用

页码：1 / 9

页数：9

共 68 条

[1] KINETIC ISOTOPE EFFECT INVESTIGATION OF ENZYME MECHANISM IN ORGANIC-SOLVENTS [J].