STEREOSPECIFIC ENZYMATIC-HYDROLYSIS OF PHOSPHORUS-SULFUR BONDS IN CHIRAL ORGANOPHOSPHATE TRIESTERS

被引:35
作者
CHAE, MY [1 ]
POSTULA, JF [1 ]
RAUSHEL, FM [1 ]
机构
[1] TEXAS A&M UNIV,DEPT CHEM,COLLEGE STN,TX 77843
关键词
D O I
10.1016/S0960-894X(01)80516-3
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The bacterial phosphotriesterase has been shown to be capable of catalyzing the hydrolysis of a P-S bond in organophosphate triesters. The V-max values for the hydrolysis of the insecticides, acephate (O, S-dimethyl N-acetylphosphoramidothioate) and methamidophos (O, S-dimethyl phosphoramidothioate) are 140 and 6 min(-1), respectively. The (Sp)-enantiomers are hydrolyzed at a rate that is 100-fold faster than the (Rp)-enantiomers.
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页码:1473 / 1478
页数:6
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