HIGHLY REGIOSELECTIVE AND RAPID RING-OPENING OF THE (METHYLENECYCLOPROPYL)METHYL RADICAL

被引：5

作者：

HORNER, JH

JOHNSON, CC

LAI, MT

LIN, HW

MARTINESKER, AA

NEWCOMB, M

OH, E

机构：

[1] WAYNE STATE UNIV,DEPT CHEM,DETROIT,MI 48202

[2] UNIV MINNESOTA,DEPT CHEM,MINNEAPOLIS,MN 55455

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(01)80698-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ring opening of the (2-methylenecyclopropyl)methyl radical (1) was studied by competition methods. Radical I rearranges to the 2-vinylallyl radical too fast to be trapped appreciably by thiophenol, but benzeneselenol trapping was possible. The rate constant for ring opening of 1 at 5 degrees C was k(r) = 3-4 x 10(9) s(-1).

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页码：2693 / 2696

页数：4

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