COPOLYMER OF SUCROSE AND NAPHTHOQUINONE IMINE DERIVATIVES - SYNTHESIS AND CHARACTERIZATION

被引：1

作者：

CASTELLANO, P ^{[1
]}

DEBERTORELLO, MM ^{[1
]}

机构：

[1] NATL UNIV CORDOBA,FAC CIENCIAS QUIM,DEPT FARM,CC 61,RA-5016 CORDOBA,ARGENTINA

来源：

POLYMER BULLETIN | 1989年 / 22卷 / 01期

关键词：

Calorimetry - Drug Products--Controlled Delivery - Spectroscopy; Infrared; -; Sugar;

D O I：

10.1007/BF00283282

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The purpose of this work was to prepare a macromolecular pro-drug with methacrylic esters of 2-hydroxy-N-(3,4-dimethyl-5-isoxazolyl)-1, 4-naphthoquinone-4-imine(I) and those of sucrose. The copolymer IV obtained by a bulk copolymerization reaction was purified by GPC and characterized by infrared spectroscopy, differential scanning calorimetry and hydrolysis studies. Its alkaline hydrolysis led to compound I which exhibited trypanocidal activity against T.cruzi.

引用

页码：41 / 45

页数：5

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