LACK OF ANXIETY IN AN ANIMAL-MODEL OF DEPRESSION WITH CHOLINERGIC SUPERSENSITIVITY

被引：24

作者：

SCHILLER, GD

DAWS, LC

OVERSTREET, DH

ORBACH, J

机构：

[1] School of Biological Sciences, Adelaide, SA 5001

来源：

BRAIN RESEARCH BULLETIN | 1991年 / 26卷 / 03期

关键词：

DEPRESSION; ANXIETY; FSL AND FRL RATS; CHOLINERGIC SUPERSENSITIVITY; ANIMAL MODEL; (+)-MAZE; DIAZEPAM;

D O I：

10.1016/0361-9230(91)90019-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It has been suggested that anxiety and depression are correlated dimensions of behaviour. Consequently, this study investigated the behaviour of the Flinders Sensitive Line, an animal model of depression with cholinergic supersensitivity, in the elevated (+)-maze test of anxiety. The results indicate that anxiety responses (% open/total arm entries) do not differ between the Flinders Sensitive and Flinders Resistant (control) lines of rat (FSL vs. FRL, respectively). Treatment with 1.0 mg/kg of diazepam significantly increased % open/total scores to a similar degree in both lines, further suggesting that the lines do not differ in anxiety. It is concluded that the FSL rat is an animal model of depression without evidence for inherent alteration in anxiety-related behaviour.

引用

页码：433 / 435

页数：3

共 7 条

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