DECREASE OF NITRATE BIOSYNTHESIS IN SCORBUTIC MUTANT RATS UNABLE TO SYNTHESIZE ASCORBIC-ACID

被引：7

作者：

KOSAKA, H

TERADA, N

ITO, Y

UOZUMI, M

机构：

[1] OSAKA MED COLL,DEPT PATHOL,TAKATSUKI,OSAKA 569,JAPAN

[2] CTR ADULT DIS,DEPT PATHOL,OSAKA 537,JAPAN

来源：

LIFE SCIENCES | 1990年 / 46卷 / 17期

关键词：

D O I：

10.1016/0024-3205(90)90500-Q

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effect of ascorbic acid deficiency on the urinary excretion of nitrate was investigated using a mutant strain of rats (osteogenic disorder syndrome rats; ODS rats) unable to synthesize ascorbic acid. The amount of urinary nitrate excreted by ODS rats with or without ascorbic acid supplementation were measured before and after the intraperitoneal injection of Escherichia coli lipopolysaccharide (LPS). Urinary nitrate excretion increased markedly after LPS injection. Urinary nitrate excretion by ODS rats not supplied with ascorbic acid was significantly less than that of thos supplied with ascorbic acid both before and after LPS injection. These results show that ascorbic acid enhances both LPS- stimulated and constitutive nitrate production in vivo. © 1990.

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页码：1249 / 1254

页数：6

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