(2-HYDROXYETHYL)-ALPHA-D-GLUCOPYRANOSIDE-2',3,4-TRISPHOSPHATE - SYNTHESIS OF A 2ND-MESSENGER MIMIC RELATED TO ADENOPHOSTIN-A

被引：21

作者：

JENKINS, DJ ^{[1
]}

POTTER, BVL ^{[1
]}

机构：

[1] UNIV BATH,SCH PHARM & PHARMACOL,DEPT MED CHEM,BATH BA2 7AY,AVON,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 11期

关键词：

D O I：

10.1039/c39950001169

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A concise synthetic route from D-glucose to a chiral, biologically active, phosphorylated analogue of the highly potent Ca2+-mobilising agonist adenophostin A has been developed, involving a regioselective dibenzylation of allyl alpha-D-glucopyranoside and a one-pot Lemieux-type allyl oxidation with subsequent reduction and neighbouring deketalisation, to provide the key intermediate for phosphorylation.

引用

页码：1169 / 1170

页数：2

共 20 条

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