ANTI-HIV AND ANTI-HCMV ACTIVITIES OF NEW AURINTRICARBOXYLIC ACID ANALOGS

被引：4

作者：

CUSHMAN, M ^{[1
]}

WANG, P ^{[1
]}

REYMEN, D ^{[1
]}

ESTE, J ^{[1
]}

WITVROUW, M ^{[1
]}

NEYTS, J ^{[1
]}

DECLERCQ, E ^{[1
]}

机构：

[1] CATHOLIC UNIV LEUVEN,REGA INST MED RES,B-3000 LOUVAIN,BELGIUM

来源：

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | 1995年 / 6卷 / 03期

关键词：

AURINTRICARBOXYLIC ACID; HCMV; HIV;

D O I：

10.1177/095632029500600307

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A variety of aurintricarboxylic acid (ATA) polymer analogues were prepared by substituting certain salicylic acid derivatives and carbonyl compounds for salicylic acid and formaldehyde in the ATA polymerization reaction. The new polymers were evaluated for prevention of the cytopathic effects of human immunodeficiency virus (HIV-1 and HIV-2) in MT-4 cell culture, HIV-1 in CEM cell culture, and human cytomegalovirus (HCMV) in HEL cell culture. The abilities of the analogues to inhibit syncytium formation between HIV-1- or HIV-2-infected HUT-78 cells and uninfected MOLT-4 cells were also evaluated. Several of the new analogues were found to be equipotent with ATA and dextran sulfate against HIV-1, HIV-2 and HCMV. The anti-HIV potencies of the new substances paralleled their activities against HCMV. The antiviral activities of the new analogues probably result from inhibition of virion binding to the cell membrane.

引用

页码：179 / 186

页数：8

共 29 条

[1] FUCHSIN ACID SELECTIVELY INHIBITS HUMAN IMMUNODEFICIENCY VIRUS (HIV) REPLICATION INVITRO [J].

BABA, M ;

SCHOLS, D ;

PAUWELS, R ;

BALZARINI, J ;

DECLERCQ, E .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 155 (03) :1404-1411

[2] HIGHLY SPECIFIC-INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 BY A NOVEL 6-SUBSTITUTED ACYCLOURIDINE DERIVATIVE [J].

BABA, M ;

TANAKA, H ;

DECLERCQ, E ;

PAUWELS, R ;

BALZARINI, J ;

SCHOLS, D ;

NAKASHIMA, H ;

PERNO, CF ;

WALKER, RT ;

MIYASAKA, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 165 (03) :1375-1381

[3] AURINTRICARBOXYLIC ACID AND EVANS BLUE REPRESENT 2 DIFFERENT CLASSES OF ANIONIC COMPOUNDS WHICH SELECTIVELY INHIBIT THE CYTOPATHOGENICITY OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-III LYMPHADENOPATHY-ASSOCIATED VIRUS [J].

BALZARINI, J ;

MITSUYA, H ;

DECLERCQ, E ;

BRODER, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 136 (01) :64-71

[4]

Caro N., 1892, CHEM BER, V25, P939

[5] PREPARATION AND ANTI-HIV ACTIVITIES OF AURINTRICARBOXYLIC ACID FRACTIONS AND ANALOGS - DIRECT CORRELATION OF ANTIVIRAL POTENCY WITH MOLECULAR-WEIGHT [J].

CUSHMAN, M ;

WANG, PL ;

CHANG, SH ;

WILD, C ;

DECLERCQ, E ;

SCHOLS, D ;

GOLDMAN, ME ;

BOWEN, JA .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (01) :329-337

[6] SYNTHESIS AND ANTI-HIV ACTIVITIES OF LOW-MOLECULAR-WEIGHT AURINTRICARBOXYLIC ACID FRAGMENTS AND RELATED-COMPOUNDS [J].

CUSHMAN, M ;

KANAMATHAREDDY, S ;

DECLERCQ, E ;

SCHOLS, D ;

GOLDMAN, ME ;

BOWEN, JA .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (01) :337-342

[7] DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF COSALANE, A NOVEL ANTI-HIV AGENT WHICH INHIBITS MULTIPLE FEATURES OF VIRUS REPRODUCTION [J].

CUSHMAN, M ;

GOLEBIEWSKI, WM ;

MCMAHON, JB ;

BUCKHEIT, RW ;

CLANTON, DJ ;

WEISLOW, O ;

HAUGWITZ, RD ;

BADER, JP ;

GRAHAM, L ;

RICE, WG .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (19) :3040-3050

[8] STRUCTURAL INVESTIGATION AND ANTI-HIV ACTIVITIES OF HIGH-MOLECULAR-WEIGHT ATA POLYMERS [J].

CUSHMAN, M ;

WANG, PL ;

STOWELL, JG ;

SCHOLS, D ;

DECLERCQ, E .

JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (26) :7241-7248

[9] SYNTHESIS OF THE COVALENT HYDRATE OF THE INCORRECTLY ASSUMED STRUCTURE OF AURINTRICARBOXYLIC ACID (ATA) [J].

CUSHMAN, M ;

KANAMATHAREDDY, S .

TETRAHEDRON, 1990, 46 (05) :1491-1498

[10] HIV-1-SPECIFIC RT INHIBITORS - HIGHLY SELECTIVE INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 THAT ARE SPECIFICALLY TARGETED AT THE VIRAL REVERSE-TRANSCRIPTASE [J].

DECLERCQ, E .

MEDICINAL RESEARCH REVIEWS, 1993, 13 (03) :229-258

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