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VERAPAMIL INHIBITS PROLIFERATION BUT NOT STEROIDOGENESIS OF REGENERATING RAT ADRENAL-CORTEX

被引：4
作者：
ZIELENIEWSKI, W
机构：
[1] Department of Clinical Endocrinology, Institute of Endocrinology, 91425 Lodz
来源：
LIFE SCIENCES | 1990年 / 46卷 / 25期
关键词：
D O I：
10.1016/0024-3205(90)90237-L
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effect of verapamil, a calcium channel antagonist, on proliferation and steroidogenesis was investigated in regenerating rat adrenal cortex. Verapamil was given subcutaneously in two doses (11 and 5 mg/kg ) to male Wistar rats subjected to adrenal enucleation combined with contralateral adrenalectomy. It was found that verapamil inhibited the mitotic activity of adrenocortical cells on the 4th and 8th day after surgery in a dose-dependent manner. However, no changes in corticosterone secretion were observed. © 1990.
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页码：1851 / 1855
页数：5
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