AMPHIDINOLIDE-E, A NOVEL ANTILEUKEMIC 19-MEMBERED MACROLIDE FROM THE CULTURED SYMBIOTIC DINOFLAGELLATE AMPHIDINIUM SP

Marine microorganisms are of considerable current interest as new promising sources of bioactive substances,2 and recently several unique secondary metabolites have been isolated from marine bacteria,3 fungi,4 cyanophytes,5 cryptophytes,6 and dinoflagellates.7 During the course of our studies on bioactive substances from Okinawan marine organisms,8 we have investigated symbiotic microalgae associated with marine invertebrates and previously isolated several new bioactive compounds from the laboratory-cultured dinoflagellates9,10 and haptophytes.11 In order to obtain more biologically useful substances from symbiotic microalgae, we investigated a dinoflagellate of the genus Amphidinium (this is a different species of Amphidinium from that reported previously9) and now isolated a new antileukemic 19-membered macrolide, amphidinolide E (1). This paper describes the isolation and structure elucidation of amphidinolide E (1). © 1990, American Chemical Society. All rights reserved.