GENETIC EPIDEMIOLOGY OF OVARIAN-CANCER - SEGREGATION ANALYSIS

被引：42

作者：

HOULSTON, RS ^{[1
]}

COLLINS, A ^{[1
]}

SLACK, J ^{[1
]}

CAMPBELL, S ^{[1
]}

COLLINS, WP ^{[1
]}

WHITEHEAD, MI ^{[1
]}

MORTON, NE ^{[1
]}

机构：

[1] KINGS COLL,SCH MED & DENT,ACAD DEPT OBSTET & GYNAECOL,LONDON SE5 8RX,ENGLAND

来源：

ANNALS OF HUMAN GENETICS | 1991年 / 55卷

关键词：

D O I：

10.1111/j.1469-1809.1991.tb00856.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The genetic epidemiology of ovarian cancer has been investigated by complex segregation analysis of 462 pedigrees ascertained through a normal consultand. The observed pattern of ovarian cancer is compatible with an autosomal dominant gene. The gene frequency of the abnormal allele is 0.0015-0.0026 with a lifetime penetrance of 0.74-0.79. The gene frequency accounts for a significant proportion of ovarian cancer in young women. By age 70 the majority of affected women are phenocopies. The results from this analysis should enable the risks of ovarian cancer to be more accurately estimated than by empiric methods for relatives of affected women, and can maximize the usefulness of screening programmes and future linkage studies.

引用

页码：291 / 299

页数：9

共 26 条

[1] Akaike H, 1974, IEEE T AUTOMAT CONTR, V19, P719
[2] BASAL CELL NEVUS SYNDROME - COMBINED CLINICAL STAFF CONFERENCE AT NATIONAL INSTITUTES OF HEALTH
BERLIN, NI
VANSCOTT, EJ
CLENDENNING, WE
ARCHARD, HO
BLOCK, JB
WITKOP, CJ
HAYNES, HA
[J]. ANNALS OF INTERNAL MEDICINE, 1966, 64 (02) : 403 - +
[3] OVARIAN TUMORS - EXTENSION OF PEUTZ-JEGHERS SYNDROME
CHRISTIAN, CD
[J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1971, 111 (04) : 529 - +
[4] CRAMER DW, 1983, JNCI-J NATL CANCER I, V71, P711
[5] EHLEN T, 1990, ONCOGENE, V5, P219
[6] GO RCP, 1983, J NATL CANCER I, V71, P455
[7] LINKAGE OF EARLY-ONSET FAMILIAL BREAST-CANCER TO CHROMOSOME-17Q21
HALL, JM
LEE, MK
NEWMAN, B
MORROW, JE
ANDERSON, LA
HUEY, B
KING, MC
[J]. SCIENCE, 1990, 250 (4988) : 1684 - 1689
[8] AN EPIDEMIOLOGIC-STUDY OF EPITHELIAL CARCINOMA OF THE OVARY
HILDRETH, NG
KELSEY, JL
LIVOLSI, VA
FISCHER, DB
HOLFORD, TR
MOSTOW, ED
SCHWARTZ, PE
WHITE, C
[J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1981, 114 (03) : 398 - 405
[9] HOULSTON RS, 1991, UNPUB BR J OBSTET GY
[10] GENETIC EPIDEMIOLOGY OF BREAST-CANCER IN BRITAIN
ISELIUS, L
SLACK, J
LITTLER, M
MORTON, NE
[J]. ANNALS OF HUMAN GENETICS, 1991, 55 : 151 - 159

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