ANALYSIS OF POLYETHYLENE-GLYCOL AND DERIVATIVES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY USING ELEVATED-TEMPERATURES AND LOW-WAVELENGTH ULTRAVIOLET DETECTION, AND SUPERCRITICAL FLUID CHROMATOGRAPHY

被引：53

作者：

ESCOTT, REA ^{[1
]}

MORTIMER, N ^{[1
]}

机构：

[1] LOUGHBOROUGH UNIV TECHNOL,LOUGHBOROUGH LE11 3TU,LEICS,ENGLAND

来源：

JOURNAL OF CHROMATOGRAPHY | 1991年 / 553卷 / 1-2期

关键词：

D O I：

10.1016/S0021-9673(01)88513-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A gradient reversed-phase high-performance liquid chromatography system is described for the characterisation of polyethylene glycols (PEGs), methoxy polyethylene glycols (MPEGs) and methoxy polyethylene glycol methacrylates. The system enables oligomeric distributions to be obtained for these types of materials with average molecular weights of up to 4000 dalton. The requirements to achieve the necessary detection and separation efficiency have been studied including the column type, operating temperature and solvent composition. The PEGs have been analysed by capillary supercritical fluid chromatography, using carbon dioxide as the mobile phase. The results obtained from the two chromatographic techniques have been compared and the relative merits discussed.

引用

页码：423 / 432

页数：10

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