EVALUATION OF RADIATION-INDUCED LIVER-INJURY WITH MR-IMAGING - COMPARISON OF HEPATOCELLULAR AND RETICULOENDOTHELIAL CONTRAST AGENTS

被引：42

作者：

CLEMENT, O ^{[1
]}

MUHLER, A ^{[1
]}

VEXLER, VS ^{[1
]}

ROSENAU, W ^{[1
]}

BERTHEZENE, Y ^{[1
]}

KUWATSURU, R ^{[1
]}

BRASCH, RC ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO, DEPT RADIOL,CONTRAST MEDIA LAB,S-372, 513 PARNASSUS AVE, SAN FRANCISCO, CA 94143 USA

来源：

RADIOLOGY | 1992年 / 185卷 / 01期

关键词：

CONTRAST MEDIA; EXPERIMENTAL STUDIES; GADOLINIUM; IRON; LIVER; EFFECTS OF IRRADIATION; MR; MAGNETIC RESONANCE (MR); CONTRAST ENHANCEMENT; RELAXOMETRY;

D O I：

10.1148/radiology.185.1.1523301

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Gadolinium (4s)-4-(4-ethoxybenzyl-3,6,9-tris(carboxylato-methyl)-3,6,9-triazaundecandioic acid (EOB) diethylenetriaminepentaacetic acid (DTPA), a hepatocellular-directed magnetic resonance (MR) contrast agent, and coated superparamagnetic iron oxide particles (SPIO), a Kupffer cell-directed contrast agent, were compared for uptake and enhancement in a rodent model of radiation-induced liver injury. A single x-irradiation exposure (50-70 Gy) was delivered to one side of the liver in 18 rats. MR imaging was performed 3 days after x irradiation with sequential injections of the two contrast agents in the same rats. Additionally, biliary excretion of Gd-EOB-DTPA was quantified after whole-liver irradiation in five rats. Electron microscopy of the irradiated liver demonstrated mitochondrial injury in both hepatocyte and Kupffer cell populations. With Gd-EOB-DTPA, however, liver enhancement and biliary excretion were not affected by irradiation. Uptake of SPIO was decreased in the irradiated portion of the liver, with a precise demarcation between irradiated and nonirradiated zones at MR imaging.

引用

页码：163 / 168

页数：6

共 32 条

[1] THE EFFECT OF HIGH DOSES OF X-IRRADIATION ON THE PHAGOCYTIC, PROLIFERATIVE, AND METABOLIC PROPERTIES OF THE RETICULO-ENDOTHELIAL SYSTEM [J].