EVOLUTIONARY VARIATION OF THE CCAAT-BINDING TRANSCRIPTION FACTOR NF-Y

被引：152

作者：

LI, XY ^{[1
]}

MANTOVANI, R ^{[1
]}

VANHUIJSDUIJNEN, RH ^{[1
]}

ANDRE, I ^{[1
]}

BENOIST, C ^{[1
]}

MATHIS, D ^{[1
]}

机构：

[1] FAC MED STRASBOURG,INST CHIM BIOL,INSERM,UNITE BIOL MOLEC & GENIE GENET 184,CNRS,STRASBOURG,FRANCE

来源：

NUCLEIC ACIDS RESEARCH | 1992年 / 20卷 / 05期

关键词：

D O I：

10.1093/nar/20.5.1087

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

NF-Y is a CCAAT-specific transcription factor thought to be involved in the regulation of a variety of eukaryotic genes. It shows a striking sequence similarity with the yeast factor HAP2/3. In an attempt to trace back its evolutionary history, we succeeded in isolating NF-Y cDNA clones from a plant and from several species of vertebrates. The patterns of sequence conservation delineate potential functional domains: A central, highly conserved, domain likely responsible for DNA-binding and subunit interaction; more evolutionarily flexible flanking regions, in which variability is clustered, individualizing conserved glutamine or acidic amino-acids putatively involved in protein-protein contacts.

引用

页码：1087 / 1091

页数：5

共 45 条

[1]

[Anonymous], 1987, MOL EVOLUTIONARY GEN, DOI DOI 10.7312/NEI-92038

[2] MUTUALLY EXCLUSIVE INTERACTION OF THE CCAAT-BINDING FACTOR AND OF A DISPLACEMENT PROTEIN WITH OVERLAPPING SEQUENCES OF A HISTONE GENE PROMOTER [J].