OVEREXPRESSION OF CELLULAR RETINOIC ACID-BINDING PROTEIN TYPE-II (CRABP-II) AND DOWN-REGULATION OF CRABP-I IN PSORIATIC SKIN

被引:24
作者
SIEGENTHALER, G [1 ]
TOMATIS, I [1 ]
DIDIERJEAN, L [1 ]
JACONI, S [1 ]
SAURAT, JH [1 ]
机构
[1] UNIV GENEVA,HOP CANTONAL,DEPT DERMATOL,CH-1211 GENEVA 4,SWITZERLAND
关键词
CELLULAR RETINOIC ACID-BINDING PROTEINS; CRABP-I; CRABP-II; PSORIASIS; HUMAN SKIN;
D O I
10.1159/000247462
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Cellular retinoic acid-binding proteins (CRABPs) might exert a physiological function by controlling the intracellular levels of free retinoic acid. The aim of this study was to analyze the relative expression of CRABP-I and CRABP-II in lesional (LPS) and nonlesional (NLPS) psoriatic skin. CRABP-I and -II proteins were analyzed by a PAGE-autoradioblotting technique, and their respective mRNA were studied by RNA blot and in situ hybridization. We found that CRABP-II levels were 6-fold higher in LPS and 2-fold in NLPS as compared to normal skin, whereas CRABP-I levels were decreased in NLPS and LPS. CRABP-II mRNA were grossly overexpressed in all LPS and some NLPS specimens. These results indicate a switch to the overexpression of CRABP-II mRNA in psoriasis which induces high levels of the protein mainly in LPS; these observations may be relevant to the pathophysiology and therapy of psoriasis as CRABP-I and -II have different ligand-binding affinities.
引用
收藏
页码:251 / 256
页数:6
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