2-DIMENSIONAL GAS-CHROMATOGRAPHY FOR THE ENANTIOMERIC SEPARATION OF EPHEDRINE AND PHENAMINUM AND THEIR METABOLITES

被引：11

作者：

WANG, XH ^{[1
]}

JIA, CR ^{[1
]}

WAN, H ^{[1
]}

机构：

[1] CHINESE ACAD SCI,LANZHOU INST CHEM PHYS,POB 97,LANZHOU 730000,PEOPLES R CHINA

来源：

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS | 1994年 / 653卷 / 01期

关键词：

D O I：

10.1016/0378-4347(93)E0413-K

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Two-dimensional gas chromatography was used for enantiomeric separation of ephedrine, phenaminum and their metabolites in human urine. The main column was coated with a 2,6-di-0-pentyl-3-O-trifluoroacetylated-alpha-cyclodextrin and an SE-54 phase column was used as precolumn. The results showed that two-dimensional chromatography could greatly simplify the sample preparation, eliminate the interference of sample matrices, and improve the resolution of the enantiomers of interest.

引用

页码：98 / 101

页数：4

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