LACK OF EFFECT OF ENALAPRILAT ON THE ACTION OF VASOACTIVE INTESTINAL POLYPEPTIDE IN THE HUMAN FOREARM

被引：2

作者：

COCKCROFT, JR ^{[1
]}

CHOWIENCZYK, P ^{[1
]}

ELLIOTT, TG ^{[1
]}

RITTER, JM ^{[1
]}

机构：

[1] UMDS,GUYS HOSP,SCH MED,DEPT METAB MED,LONDON SE1 9RT,ENGLAND

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1993年 / 35卷 / 05期

关键词：

VASOACTIVE INTESTINAL POLYPEPTIDE; CONVERTING ENZYME; ANGIOTENSIN; FOREARM BLOOD FLOW; MAN;

D O I：

10.1111/j.1365-2125.1993.tb04179.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

It has been proposed that angiotensin converting enzyme (ACE) may play a role in the metabolism of the vasodilator peptide vasoactive intestinal polypeptide (VIP). Reduced metabolism following treatment with ACE inhibitors may cause accumulation of VIP which in turn may mediate some of the beneficial haemodynamic effects of ACE inhibition observed in patients with heart failure. This study has shown that inhibition of local vascular ACE does not interfere with the vascular effects of VIP on forearm resistance vessels when this peptide is infused into the brachial artery of normal volunteers. These results suggest that endothelial ACE plays little part in the metabolism of intravascular VIP.

引用

页码：525 / 527

页数：3

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