PERIPHERAL OSTEOPENIA IN ADULT PATIENTS WITH INSULIN-DEPENDENT DIABETES-MELLITUS

被引：78

作者：

FORST, T ^{[1
]}

PFUTZNER, A ^{[1
]}

KANN, P ^{[1
]}

SCHEHLER, B ^{[1
]}

LOBMANN, R ^{[1
]}

SCHAFER, H ^{[1
]}

ANDREAS, J ^{[1
]}

BOCKISCH, A ^{[1
]}

BEYER, J ^{[1
]}

机构：

[1] UNIV HOSP MAINZ,DEPT ENDOCRINOL & INTERNAL MED,D-55101 MAINZ,GERMANY

来源：

DIABETIC MEDICINE | 1995年 / 12卷 / 10期

关键词：

BONE MINERAL DENSITY; DIABETIC LIMB; DIABETIC NEUROPATHY;

D O I：

10.1111/j.1464-5491.1995.tb00389.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Alterations in bone metabolism in diabetes mellitus is a topic of special interest. Bone blood flow is increased in the distal limb of diabetic patients, which is believed to increase osteoclastic activity. We measured bone mineral density using dual-photon absorptiometry in the distal lower limb, the femoral neck, and the lumbar spine in 41 IDDM patients and in 30 control persons. In the diabetic group there was a 10 % reduction of bone mineral density in the femoral neck (p < 0.01) and a 12 % reduction in the distal limb (p < 0.001) compared with the control group. No significant difference was found in the lumbar spine (p = 0.22). Our data yield incidence for peripheral osteopenia in IDDM-patients, independent of any systemic bone diseases such as osteoporosis. A link between decreased bone mineral density and diabetic neuropathy has been observed for the femoral neck (p < 0.001), but not for the distal limb or axial skeleton. Whether there is a common aetiological link or a causal connection between diabetic neuropathy and bone mineral density has still to be determined.

引用

页码：874 / 879

页数：6

共 32 条

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