CHOLECYSTOKININ IS RELEASED FROM A CROSSED CORTICOSTRIATAL PATHWAY

被引：25

作者：

HERRERAMARSCHITZ, M ^{[1
]}

MEANA, JJ ^{[1
]}

HOKFELT, T ^{[1
]}

YOU, ZB ^{[1
]}

MORINO, P ^{[1
]}

BRODIN, E ^{[1
]}

UNGERSTEDT, U ^{[1
]}

机构：

[1] KAROLINSKA INST,DEPT HISTOL & NEUROBIOL,S-10401 STOCKHOLM 60,SWEDEN

来源：

NEUROREPORT | 1992年 / 3卷 / 10期

关键词：

BASAL GANGLIA; NEUROPEPTIDES; DOPAMINE; GLUTAMATE; ASPARTATE; MICRODIALYSIS; RAT;

D O I：

10.1097/00001756-199210000-00021

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE release of striatal cholecystokinin, glutamate, aspartate and dopamine was studied in vivo with microdialysis in decorticated rats, with or without callosotomy. Unlesioned rats were also analysed. Unilateral decortication produced a unilateral decrease in K+-stimulated extra-cellular striatal glutamate and aspartate levels, without decreasing cholecystokinin or dopamine levels. However, following decortication plus callosotomy, basal and K+-stimulated extracellular cholecystokinin and glutamate levels were significantly decreased in the striatum ipsilateral to side of decortication. Aspartate levels were bilaterally decreased. These results give evidence for the existence of crossed corticostriatal projections containing releasable cholecystokinin and glutamate.

引用

页码：905 / 908

页数：4

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