BIODISTRIBUTION AND METABOLISM OF ORALLY-ADMINISTERED OCTACOSANOL IN RATS

被引：48

作者：

KABIR, Y ^{[1
]}

KIMURA, S ^{[1
]}

机构：

[1] TOHOKU UNIV,FAC AGR,DEPT FOOD CHEM,NUTR LAB,SENDAI,MIYAGI 980,JAPAN

来源：

ANNALS OF NUTRITION AND METABOLISM | 1993年 / 37卷 / 01期

关键词：

OCTACOSANOL; BIODISTRIBUTION; METABOLISM; ADIPOSE TISSUE; PHYSICAL EXERCISE;

D O I：

10.1159/000177746

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The biodistribution and metaboliSM of [8-C-14]-octacosanol in rats were investigated to understand the mechanism of increased physical exercise and motor endurance by octacosanol. After C-14-octacosanol administered, radioactivity of octacosanol was mainly found in adipose tissue, especially in brown adipose tissue. Absorption of octacosanol is very low and mainly excreted through feces. The radioactivity of octacosanol was also partly expired as (Co2)-C-14. About 49% of the administered dose were excreted through different pathways. Metabolites of octacosanol are present in the urine. Octacosanol may be partly oxidized and degraded to fatty acids through beta-oxidation.

引用

页码：33 / 38

页数：6

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