FUNCTIONAL ISOFORMS OF PIT-1 GENERATED BY ALTERNATIVE MESSENGER-RNA SPLICING

被引：94

作者：

KONZAK, KE ^{[1
]}

MOORE, DD ^{[1
]}

机构：

[1] MASSACHUSETTS GEN HOSP, DEPT MOLEC BIOL, BOSTON, MA 02114 USA

来源：

MOLECULAR ENDOCRINOLOGY | 1992年 / 6卷 / 02期

关键词：

D O I：

10.1210/me.6.2.241

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pit-1 is a pituitary-specific transcription factor that activates expression of the GH and PRL genes. We have isolated a cDNA encoding a variant isoform of Pit-1 that we term Pit-1-beta. Pit-1-beta contains an insertion of 26 amino acids in the transactivation domain as a consequence of the utilization of an alternative 3' splice acceptor at the end of the first intron. Like the previously described Pit-1-alpha, Pit-1-beta transactivates both the GH and PRL promoters. However, the larger isoform acts as a more potent inducer of GH.

引用

页码：241 / 247

页数：7

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