SYNTHESIS OF ALLYL 6-O-(3-DEOXY-ALPHA-D-MANNO-OCT-2-ULOPYRANOSYLONIC ACID AND 3-DEOXY-BETA-D-MANNO-OCT-2-ULOPYRANOSYLONIC ACID)-(1-]6)-2-DEOXY-2-[(3R)-3-HYDROXYTETRADECANAMIDO]-BETA-D-GLUCOPYRANOSIDE 4-PHOSPHATE AND OF THE COPOLYMER OF THE ALPHA ANOMER WITH ACRYLAMIDE

被引：5

作者：

AUZANNEAU, FI ^{[1
]}

MONDANGE, M ^{[1
]}

CHARON, D ^{[1
]}

SZABO, L ^{[1
]}

机构：

[1] UNIV PARIS 11, CTR ETUD PHARMACEUT,CNRS,URA 1116, EQUIPE ENDOTOXINES, F-92290 CHATENAY MALABRY, FRANCE

来源：

CARBOHYDRATE RESEARCH | 1992年 / 228卷 / 01期

关键词：

D O I：

10.1016/S0008-6215(00)90547-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The title disaccharides were synthesized by mercuric cyanide-catalyzed condensation of methyl (4,5,7,8-tetra-O-acetyl-3-deoxy-alpha-D-manno-oct-2-ulopyranosyl bromide)onate and allyl 2-[(3 R)-3-acetoxy-tetradecanamido]-3-O-benzyl-2-deoxy-beta-D-glucopyranoside, followed by phosphorylation of the alcoholic function of the amino sugar. The phosphorylated anomers were separated by chromatography and deprotected by conventional methods. Polymeric material was obtained by copolymerisation, catalyzed by peroxosulphate and N,N,N',N"-tetramethylethylenediamine, of the alpha anomer with acrylamide; it contained ca. one disaccharide unit for 18 acrylamide residues.

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页码：37 / 45

页数：9

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