SYNTHESIS OF PROTECTED NONPROTEINURIC ALPHA-AMINO-ACIDS AND OLIGOPEPTIDES FROM 2H-1,3-OXAZINES AND 2H-1,3-BENZOXAZINES VIA UGI REACTION

被引：28

作者：

GROGER, H ^{[1
]}

HATAM, M ^{[1
]}

MARTENS, J ^{[1
]}

机构：

[1] UNIV OLDENBURG,FACHBEREICH CHEM,D-26111 OLDENBURG,GERMANY

来源：

TETRAHEDRON | 1995年 / 51卷 / 26期

关键词：

D O I：

10.1016/0040-4020(95)00365-F

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of six-membered N,O-heterocyclic 2H-1,3-oxazines 1 and 2H-1,3-benzoxazines 2 and the use of them in the synthesis of the corresponding alpha-amino acids 3a-c, 4a-c and oligopeptides 3d,e, 4d-f are described These compounds are prepared based on the Ugi four-component-condensation reaction.

引用

页码：7173 / 7180

页数：8

共 15 条

[1]

BALIAH V, 1978, INDIAN J CHEM B, V16, P1065

[2]

BOHME A, 1978, LIEBIGS ANN CHEM, P1928

[3]

COTZIAS GC, 1969, NEW ENGL J MED, V280, P377

[4] A NEW 5,6-DIHYDRO-2H-1,3-OXAZINE SYNTHESIS VIA ASINGER-TYPE CONDENSATION [J].

DOMLING, A ;

UGI, IK .

TETRAHEDRON, 1993, 49 (42) :9495-9500

[5]

HATAM M, 1994, SYNTHESIS-STUTTGART, P619

[6] NEW HUMAN RENIN INHIBITORS CONTAINING AN UNNATURAL AMINO-ACID, NORSTATINE [J].

IIZUKA, K ;

KAMIJO, T ;

KUBOTA, T ;

AKAHANE, K ;

UMEYAMA, H ;

KISO, Y .

JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (04) :701-704

[7]

KINTSCHER J, 1992, SYNTHESIS-STUTTGART, P837

[8]

KINTSCHERLANGEN.J, 1992, THESIS U OLDENBURG

[9]

MIMOTO T, 1992, CHEM PHARM BULL, V40, P2251

[10]

PICKARD PL, 1963, J ORG CHEM, V26, P4886

← 1 2 →