POTENTIAL PYROPHOSPHATE FORMATION UPON USE OF N-ALPHA-FMOC-TYR(PO3H2)-OH IN SOLID-PHASE PEPTIDE-SYNTHESIS

被引：18

作者：

GARCIAECHEVERRIA, C ^{[1
]}

机构：

[1] CIBA GEIGY AG, DIV PHARMACEUT, CH-4002 BASEL, SWITZERLAND

来源：

LETTERS IN PEPTIDE SCIENCE | 1995年 / 2卷 / 02期

关键词：

PHOSPHOTYROSINE; PHOSPHOPEPTIDE; EGFR; SIGNAL TRANSDUCTION PATHWAYS;

D O I：

10.1007/BF00128503

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series. of peptides related to some of the autophosphorylation sites of the epidermal growth factor receptor has been synthesized on solid phase, using side-chain-unprotected phosphotyrosine. Although the desired peptides could be obtained, this approach was not entirely satisfactory due to a side reaction that gave the pyrophosphate derivative of the target peptide. Under identical coupling conditions, the extension of this side reaction appears to be sequence dependent.

引用

页码：93 / 98

页数：6

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