A SHORT AND SIMPLE SYNTHESIS OF THE ANTITUMOR AGENT ETOPOSIDE

被引：12

作者：

ALLEVI, P ^{[1
]}

ANASTASIA, M ^{[1
]}

CIUFFREDA, P ^{[1
]}

SANVITO, AM ^{[1
]}

MACDONALD, P ^{[1
]}

机构：

[1] SICOR SPA RHO,MILAN,ITALY

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 33期

关键词：

D O I：

10.1016/S0040-4039(00)61297-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

the antitumor agent etoposide has been synthesized for the first time from unprotected 4'-demethylepipodophyllotoxin.

引用

页码：4831 / 4834

页数：4

共 21 条

[1] A SHORT AND SIMPLE SYNTHESIS OF THE THIOGLUCOSE ANALOG OF THE ANTITUMOR AGENT ETOPOSIDE [J].

ALLEVI, P ;

ANASTASIA, M ;

CIUFFREDA, P .

TETRAHEDRON LETTERS, 1991, 32 (47) :6927-6930

[2]

ALLEVI P, UNPUB CARBOHYDR RES

[3] CONFORMATIONAL-ANALYSIS OF PODOPHYLLOTOXIN AND ITS CONGENERS - STRUCTURE-ACTIVITY RELATIONSHIP IN MICROTUBULE ASSEMBLY [J].

BREWER, CF ;

LOIKE, JD ;

HORWITZ, SB ;

STERNLICHT, H ;

GENSLER, WJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1979, 22 (03) :215-221

[4]

FIANDOR J, 1985, SYNTHESIS-STUTTGART, V12, P1121

[5] PODOPHYLLOTOXIN-PICROPODOPHYLLIN EQUILIBRIUM [J].

GENSLER, WJ ;

GATSONIS, CD .

JOURNAL OF ORGANIC CHEMISTRY, 1966, 31 (10) :3224-+

[6]

GUPTA RS, 1987, ANTI-CANCER DRUG DES, V2, P1

[7] A NEW AND GENERAL GLYCOSIDATION METHOD FOR PODOPHYLLUM LIGNAN GLYCOSIDES [J].

HASHIMOTO, S ;

HONDA, T ;

IKEGAMI, S .

TETRAHEDRON LETTERS, 1991, 32 (13) :1653-1654

[8]

HOLM C, 1991, DNA TOPOISOMERASES C, P161

[9]

JARDINE I, 1980, PODOPHYLLOTOXINS ANT, P319

[10] SYNTHESIS OF ETOPOSIDE LACTAM VIA A MITSUNOBU REACTION SEQUENCE [J].

KADOW, JF ;

VYAS, DM ;

DOYLE, TW .

TETRAHEDRON LETTERS, 1989, 30 (25) :3299-3302

← 1 2 3 →