IS DECREASED ACTIVITY OF C-II ACTIVATED LIPOPROTEIN-LIPASE IN TYPE-III HYPERLIPOPROTEINEMIA (BROAD-BETA-DISEASE) A CAUSE OR AN EFFECT OF INCREASED APOLIPOPROTEIN E LEVELS

被引：35

作者：

GANESAN, D

BASS, HB

MCCONATHY, WJ

ALAUPOVIC, P

机构：

[1] OKLAHOMA MED RES FDN, PROGRAM CARDIOVASC RES, OKLAHOMA CITY, OK 73104 USA

[2] OKLAHOMA MED RES FDN, LIPOPROTEIN LAB, OKLAHOMA CITY, OK 73104 USA

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 1976年 / 25卷 / 11期

关键词：

D O I：

10.1016/S0026-0495(76)80001-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Apolipoprotein E (ApoE; arginine-rich polypeptide) strongly inhibited both C-I and C-II activated lipoprotein lipases [human] but not the protamine insensitive triglyceride lipase. Inhibition of lipoprotein lipases by ApoE in contrast to inhibition by C-III was not reversed to any significant extent by either increased concentration of activator or triglyceride in the substrate. Previous studies showed that in a type III hyperlipoproteinemia (broad-.beta.-disease) a post-heparin plasma lipoprotein lipase activated by C-II polypeptide of lipoprotein C is decreased in enzyme activity and exhibits an impaired ability to hydrolyze triglycerides in very low density lipoproteins. Type III patients are characterized by elevated concentrations of ApoE in the serum. The decreased C-II activated lipoprotein lipase may be further aggravated by increased ApoE levels. Since this enzyme is involved in the catabolism and removal of lipoproteins, decreased activity of C-II activated lipoprotein lipase may presumably be responsible for increased ApoE.

引用

页码：1189 / 1195

页数：7

共 13 条

[1] STUDIES ON COMPOSITION AND STRUCTURE OF PLASMA LIPOPROTEINS DISTRIBUTION OF LIPOPROTEIN FAMILIES IN MAJOR DENSITY CLASSES OF NORMAL HUMAN PLASMA LIPOPROTEINS [J].