DNA STRAND BREAK METABOLISM IN HUMAN-LYMPHOCYTES - A REEVALUATION

被引：14

作者：

BOERRIGTER, METI

机构：

[1] Harvard Medical School, Beth Israel Hospital, Gerontology Division, Boston, MA 02215

来源：

EXPERIMENTAL CELL RESEARCH | 1991年 / 196卷 / 01期

关键词：

D O I：

10.1016/0014-4827(91)90448-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent findings concerning the presumed existence of single-strand breaks (SSB) in quiescent human peripheral blood lymphocytes (PBL) are discussed in relation to the role of poly(ADP-ribosyl)ation in DNA strand break metabolism. It is argued that the activation of poly(ADP-ribose)polymerase (ADPRP) by a DNA-damaging agent is not indicative of an obligatory role of poly(ADP-ribosyl)ation in DNA repair. From this it follows that SSB induced by different strand-breaking agents might be removed by either ADPRP-dependent or ADPRP-independent DNA repair pathways. © 1991.

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页码：1 / 5

页数：5

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