INHIBITION OF PROLIFERATION AND INDUCTION OF DIFFERENTIATION OF HUMAN AND MOUSE MYELOID-LEUKEMIA CELLS BY NEW ETHYLENEGLYCOL-TYPE NONPHOSPHORUS ALKYL ETHER LIPIDS

被引：22

作者：

KASUKABE, T ^{[1
]}

HONMA, Y ^{[1
]}

HOZUMI, M ^{[1
]}

NOMURA, H ^{[1
]}

机构：

[1] TAKEDA CHEM IND LTD,DIV CENT RES,YODOGAWA KU,OSAKA 532,JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1990年 / 81卷 / 08期

关键词：

Alkyl ether lipids; Differentiation; Growth inhibition; HL‐60; cells; Myeloid leukemia;

D O I：

10.1111/j.1349-7006.1990.tb02649.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A variety of ethyleneglycol‐type nonphosphorus alkyl ether lipids, ether derivatives of diethylene‐glycol in which the two hydroxyl groups were substituted with long chain alkyl and quaternary ammonioalkyl groups, were synthesized and their effects on proliferation and differentiation of cultured human (HL‐60) and mouse (M1) myeloid leukemia cells were studied. Incubation with these compounds inhibited the cellular proliferation, and the cells differentiated into morphologically and functionally mature granulocytes. Of the compounds tested, 1‐[2‐[2‐(octadecyloxy)ethoxy]ethoxy]‐butylpyridinium mesylate (EG‐6) was the most effective in inducing differentiation of HL‐60 cells. Almost maximal induction of differentiation and inhibition of growth of HL‐60 cells on day 6 were observed when the cells were treated with EG‐6 for 1 day and then cultured without EG‐6 for a further 5 days. The inhibitory effect of EG‐6 on the leukemic cells was over 100 times more than that of 2‐[2‐(dodecyloxy)ethoxy]ethyl 2‐pyridinioethyl phosphate, a potent antileukemic ether phospholipid. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：807 / 812

页数：6

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