SULFATED GLYCOPROTEIN-2 (SGP-2) MESSENGER-RNA IS EXPRESSED IN RAT STRIATAL ASTROCYTES FOLLOWING IBOTENIC ACID LESIONS

被引：52

作者：

PASINETTI, GM ^{[1
]}

FINCH, CE ^{[1
]}

机构：

[1] UNIV SO CALIF,ETHEL PERCY ANDRUS GERONTOL CTR,DEPT BIOL SCI,LOS ANGELES,CA 90089

来源：

NEUROSCIENCE LETTERS | 1991年 / 130卷 / 01期

关键词：

SULFATED GLYCOPROTEIN-2 (SGP-2); GLIAL FIBRILLARY ACID PROTEIN (GFAP); IBOTENIC ACID; ASTROCYTE; INSITU HYBRIDIZATION; GENE EXPRESSION;

D O I：

10.1016/0304-3940(91)90213-D

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A combination of in situ hybridization and immunocytochemistry (ICC) was used to identify the cells that contain mRNA for sulfated glycoprotein-2 (SGP-2) in adult male rats after striatal ibotenic acid (IA) lesioning. Astrocytic responses were monitored by ICC for glial fibrillary acidic protein (GFAP). IA lesioning that caused death of striatal neurons also stimulated astrocytic responses as monitored by GFAP and SGP-2. The SGP-2 immunoreactivity showed punctate deposits in the lesioned striatum without any apparent cellular localization. By in situ hybridization combined with ICC, SGP-2 mRNA was localized in astrocytes that were GFAP-immunopositive. These data suggest that reactive astrocytes may express SGP-2 which may be eventually secreted.

引用

页码：1 / 4

页数：4

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