ASSOCIATION OF GASTRIC HYPOACIDITY WITH OPPORTUNISTIC ENTERIC INFECTIONS IN PATIENTS WITH AIDS

被引:67
作者
BELITSOS, PC
GREENSON, JK
YARDLEY, JH
SISLER, JR
BARTLETT, JG
机构
[1] JOHNS HOPKINS UNIV, SCH MED, DEPT MED, BALTIMORE, MD 21205 USA
[2] JOHNS HOPKINS UNIV, SCH MED, DEPT PATHOL, BALTIMORE, MD 21205 USA
关键词
D O I
10.1093/infdis/166.2.277
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To determine the relation and possible significance of gastric hypoaciditity to chronic diarrhea in AIDS, patients with and without chronic (>1 month) diarrhea underwent fasting gastric juice pH measurement and microbiologic study and upper and lower endoscopy with biopsy. All 8 patients with diarrhea and high gastric pH (>3; mean, 6.1 +/- 1.0) had gastric bacterial overgrowth (>10(4) bacteria/mL) along with opportunistic enteropathogens in the duodenum or rectosigmoid, but only 1 of 6 patients with diarrhea and gastric pH in the normal range (less-than-or-equal-to 3; mean, 1.9 +/- 0.7) had overgrowth or an opportunistic enteropathogen. By contrast, all but 1 of 9 controls (AIDS patients without diarrhea) had normal fasting gastric pH (mean, 2.9 +/- 1.5). Overall, the presence of gastric hypoacidity was associated with identification of opportunistic enteropathogens (P = .035). Thus, gastric hypoacidity is associated with quantitative bacterial overgrowth and opportunistic enteric infections and may be etiologically important in the pathophysiology of the chronic diarrhea seen in some AIDS patients.
引用
收藏
页码:277 / 284
页数:8
相关论文
共 35 条
  • [1] GASTRITIS AND CAMPYLOBACTER-PYLORI IN HEALTHY, ASYMPTOMATIC VOLUNTEERS
    BARTHEL, JS
    WESTBLOM, TU
    HAVEY, AD
    GONZALEZ, F
    EVERETT, ED
    [J]. ARCHIVES OF INTERNAL MEDICINE, 1988, 148 (05) : 1149 - 1151
  • [2] BUDHRAJA M, 1987, AM J GASTROENTEROL, V82, P427
  • [3] POSTMARKETING SURVEILLANCE OF THE SAFETY OF CIMETIDINE - 12 MONTH MORTALITY REPORT
    COLINJONES, DG
    LANGMAN, MJS
    LAWSON, DH
    VESSEY, MP
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 1983, 286 (6379): : 1713 - 1716
  • [4] PREVALENCE OF HELICOBACTER-PYLORI INFECTION AND HISTOLOGIC GASTRITIS IN ASYMPTOMATIC PERSONS
    DOOLEY, CP
    COHEN, H
    FITZGIBBONS, PL
    BAUER, M
    APPLEMAN, MD
    PEREZPEREZ, GI
    BLASER, MJ
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (23) : 1562 - 1566
  • [5] DRASAR BS, 1969, GASTROENTEROLOGY, V56, P71
  • [6] DWORKIN B, 1985, AM J GASTROENTEROL, V80, P774
  • [7] ACQUIRED IMMUNODEFICIENCY SYNDROME - EPIDEMIOLOGIC, CLINICAL, IMMUNOLOGICAL, AND THERAPEUTIC CONSIDERATIONS
    FAUCI, AS
    MACHER, AM
    LONGO, DL
    LANE, HC
    ROOK, AH
    MASUR, H
    GELMANN, EP
    [J]. ANNALS OF INTERNAL MEDICINE, 1984, 100 (01) : 92 - 106
  • [8] GASTRIC-ACID BARRIER TO INGESTED MICROORGANISMS IN MAN - STUDIES IN-VIVO AND IN-VITRO
    GIANNELLA, RA
    ZAMCHECK, N
    BROITMAN, SA
    [J]. GUT, 1972, 13 (04) : 251 - +
  • [9] INFLUENCE OF GASTRIC ACIDITY ON BACTERIAL AND PARASITIC ENTERIC INFECTIONS - PERSPECTIVE
    GIANNELLA, RA
    BROITMAN, SA
    ZAMCHECK, N
    [J]. ANNALS OF INTERNAL MEDICINE, 1973, 78 (02) : 271 - 276
  • [10] MALABSORPTION AND MUCOSAL ABNORMALITIES OF THE SMALL-INTESTINE IN THE ACQUIRED IMMUNODEFICIENCY SYNDROME
    GILLIN, JS
    SHIKE, M
    ALCOCK, N
    URMACHER, C
    KROWN, S
    KURTZ, RC
    LIGHTDALE, CJ
    WINAWER, SJ
    [J]. ANNALS OF INTERNAL MEDICINE, 1985, 102 (05) : 619 - 622