CHLOMIPRAMINE DIFFERENTLY AFFECTS INFLAMMATORY EDEMA AND PAIN IN THE RAT

被引：30

作者：

BIANCHI, M

SACERDOTE, P

PANERAI, AE

机构：

[1] Department of Pharmacology, University of Milano, 20129 Milano, Via Vanvitelli

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1994年 / 48卷 / 04期

关键词：

CHLOMIPRAMINE; EDEMA; HYPERALGESIA; INFLAMMATION;

D O I：

10.1016/0091-3057(94)90217-8

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

In the rat, the acute administration of the antidepressant drug chlomipramine significantly reduces the edema and the hyperalgesia induced by yeast injection in the paw. However, the intensity and time course of the two effects differ. Moreover, adrenalectomy enhances the antinociceptive effect, whereas it does not affect the antiedema action of chlomipramine. Our data suggest a dissociation between the antiinflammatory and the analgesic effect of acute chlomipramine.

引用

页码：1037 / 1040

页数：4

共 19 条

[1]

ANSTEE J, 1979, PHARM MED, V1, P78

[2]

ARRIGONIMARTELL.E, 1967, EUR J PHARMACOL, V2, P229

[3]

BIANCHI M, 1988, ARCH INT PHARMACOD T, V295, P34

[4] REDUCTION OF ARTHRITIS AND PAIN BEHAVIOR FOLLOWING CHRONIC ADMINISTRATION OF AMITRIPTYLINE OR IMIPRAMINE IN RATS WITH ADJUVANT-INDUCED ARTHRITIS [J].

BUTLER, SH ;

WEILFUGAZZA, J ;

GODEFROY, F ;

BESSON, JM .

PAIN, 1985, 23 (02) :159-175

[5]

DEKLOET ER, 1986, NEUROENDOCRINOLOGY, V42, P513

[6] IMMUNOCYTOCHEMICAL STUDIES ON THE LOCALIZATION OF GLUCOCORTICOID RECEPTOR IMMUNOREACTIVE NERVE-CELLS IN THE LOWER BRAIN-STEM AND SPINAL-CORD OF THE MALE-RAT USING A MONOCLONAL-ANTIBODY AGAINST RAT-LIVER GLUCOCORTICOID RECEPTOR [J].

FUXE, K ;

HARFSTRAND, A ;

AGNATI, LF ;

YU, ZY ;

CINTRA, A ;

WIKSTROM, AC ;

OKRET, S ;

CANTONI, E ;

GUSTAFSSON, JA .

NEUROSCIENCE LETTERS, 1985, 60 (01) :1-6

[7]

JOELS M, 1991, J NEUROSCI, V11, P2288

[8]

MAJ J, 1984, REV PHYSIOL BIOCH P, V100, P1

[9]

Panerai A E, 1991, J Palliat Care, V7, P42

[10]

PANERAI AE, 1990, ACTA NEUROL SCAND, V82, P34

← 1 2 →