THE HUMAN LEUKEMIA-CELL LINE, THP-1 - A MULTIFACETED MODEL FOR THE STUDY OF MONOCYTE-MACROPHAGE DIFFERENTIATION

被引：674

作者：

AUWERX, J ^{[1
]}

机构：

[1] CATHOLIC UNIV LEUVEN, DEPT DEV BIOL, EXP MED & ENDOCRINOL LAB, CAMPUS GASTHUISBERG, B-3000 LOUVAIN, BELGIUM

来源：

EXPERIENTIA | 1991年 / 47卷 / 01期

关键词：

ATHEROSCLEROSIS; CELLULAR DIFFERENTIATION; GENE EXPRESSION; FOAM CELLS; LIPOPROTEINS; PHORBOL ESTERS; TRANSCRIPTION FACTORS;

D O I：

10.1007/BF02041244

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

THP-1 is a human monocytic leukemia cell line. After treatment with phorbol esters, THP-1 cells differentiate into macrophage-like cells which mimic native monocyte-derived macrophages in several respects. Compared to other human myeloid cell lines, such as HL-60, U937, KG-1, or HEL cell lines, differentiated THP-1 cells behave more like native monocyte-derived macrophages. Because of these characteristics, the THP-1 cell line provides a valuable model for studying the mechanisms involved in macrophage differentiation, and for exploring the regulation of macrophage-specific genes as they relate to physiological functions displayed by these cells.

引用

页码：22 / 31

页数：10

共 110 条

[1] THE CELL BIOLOGY OF MACROPHAGE ACTIVATION [J].